1 00:00:09,270 --> 00:00:07,349 science of course remains the name of 2 00:00:10,950 --> 00:00:09,280 the game aboard the international space 3 00:00:12,709 --> 00:00:10,960 station and we've all heard the saying 4 00:00:14,150 --> 00:00:12,719 you are what you eat 5 00:00:15,669 --> 00:00:14,160 well there's several space station 6 00:00:17,590 --> 00:00:15,679 experiments that have looked into what 7 00:00:19,910 --> 00:00:17,600 crews are eating and how their diet may 8 00:00:23,429 --> 00:00:19,920 affect things such as bone loss muscle 9 00:00:24,950 --> 00:00:23,439 loss and also vision issues or problems 10 00:00:27,269 --> 00:00:24,960 in order to do that samples are 11 00:00:29,509 --> 00:00:27,279 collected on orbit of blood and urine 12 00:00:31,589 --> 00:00:29,519 periodically when those are returned to 13 00:00:33,430 --> 00:00:31,599 earth those samples have to go someplace 14 00:00:36,389 --> 00:00:33,440 and that place is where we find my 15 00:00:38,150 --> 00:00:36,399 colleague lori meggs who visited one of 16 00:00:40,790 --> 00:00:38,160 our labs here at the johnson space 17 00:00:43,590 --> 00:00:40,800 center to learn more about nutrition and 18 00:00:44,869 --> 00:00:43,600 biochemistry 19 00:00:46,389 --> 00:00:44,879 we're talking blood and urine today 20 00:00:48,229 --> 00:00:46,399 nobody likes to talk about it but dr 21 00:00:49,830 --> 00:00:48,239 scott smith has to deal with it when the 22 00:00:52,069 --> 00:00:49,840 samples come back from the space station 23 00:00:53,110 --> 00:00:52,079 they come to this lab tell us about that 24 00:00:55,189 --> 00:00:53,120 well we 25 00:00:56,069 --> 00:00:55,199 we are the nutritional biochemistry lab 26 00:00:57,590 --> 00:00:56,079 and 27 00:00:58,869 --> 00:00:57,600 i usually like to draw the distinction 28 00:01:00,310 --> 00:00:58,879 that there's a food lab here at nasa 29 00:01:01,590 --> 00:01:00,320 that makes the food 30 00:01:04,229 --> 00:01:01,600 we are not the food lab we are the 31 00:01:06,070 --> 00:01:04,239 nutrition lab um and our job is to 32 00:01:07,270 --> 00:01:06,080 understand the nutritional requirements 33 00:01:09,190 --> 00:01:07,280 of the body 34 00:01:10,550 --> 00:01:09,200 and what the body needs how much calcium 35 00:01:12,149 --> 00:01:10,560 how much iron how much zinc how much 36 00:01:14,070 --> 00:01:12,159 protein 37 00:01:14,950 --> 00:01:14,080 and the way we get at that is by looking 38 00:01:16,789 --> 00:01:14,960 at 39 00:01:18,630 --> 00:01:16,799 blood and urine samples by collecting 40 00:01:20,149 --> 00:01:18,640 blood in urine it can tell us 41 00:01:23,030 --> 00:01:20,159 what's going on in the body what your 42 00:01:26,310 --> 00:01:23,040 bones are doing what your muscles doing 43 00:01:27,830 --> 00:01:26,320 fuel homeostasis lots of things 44 00:01:29,510 --> 00:01:27,840 come out of blood and urine and there's 45 00:01:31,910 --> 00:01:29,520 a lot of things to learn from that and 46 00:01:34,149 --> 00:01:31,920 the difference in microgravity that's on 47 00:01:35,109 --> 00:01:34,159 earth absolutely so how do you do that 48 00:01:37,429 --> 00:01:35,119 well 49 00:01:39,270 --> 00:01:37,439 a lot of the basic sample processing 50 00:01:41,270 --> 00:01:39,280 happens in this lab 51 00:01:42,789 --> 00:01:41,280 when we collect samples on earth before 52 00:01:44,230 --> 00:01:42,799 and after flight 53 00:01:46,469 --> 00:01:44,240 the crews will carry around a bag that 54 00:01:47,910 --> 00:01:46,479 has bottles in it for their urine 55 00:01:49,910 --> 00:01:47,920 we'll go meet up with them and stick a 56 00:01:51,109 --> 00:01:49,920 needle in them and collect some blood 57 00:01:52,950 --> 00:01:51,119 and that all comes back here for 58 00:01:54,310 --> 00:01:52,960 processing 59 00:01:55,749 --> 00:01:54,320 when we collect urine and blood in 60 00:01:57,590 --> 00:01:55,759 flight the blood collection is the same 61 00:02:00,230 --> 00:01:57,600 thing um 62 00:02:01,590 --> 00:02:00,240 again it's a needle some tubes 63 00:02:03,190 --> 00:02:01,600 sometimes the crews will draw their own 64 00:02:04,389 --> 00:02:03,200 blood which gets interesting because 65 00:02:06,550 --> 00:02:04,399 they will 66 00:02:08,710 --> 00:02:06,560 we train them ahead of time 67 00:02:11,270 --> 00:02:08,720 and they will voluntarily decide to 68 00:02:13,030 --> 00:02:11,280 stick themselves um which has worked out 69 00:02:14,790 --> 00:02:13,040 really really well we've been 70 00:02:18,070 --> 00:02:14,800 collecting blood for a little over for 71 00:02:19,270 --> 00:02:18,080 almost 10 years um onboard space station 72 00:02:21,430 --> 00:02:19,280 um 73 00:02:22,869 --> 00:02:21,440 and uh the crews have done phenomenally 74 00:02:23,910 --> 00:02:22,879 well now i would think the urine is a 75 00:02:25,510 --> 00:02:23,920 little trickier though the urine is a 76 00:02:26,869 --> 00:02:25,520 little trickier i would say we've had a 77 00:02:28,470 --> 00:02:26,879 lot of folks collect urine in flight not 78 00:02:31,270 --> 00:02:28,480 one of them has come back and said 79 00:02:32,550 --> 00:02:31,280 that's a great way to collect hearing 80 00:02:35,750 --> 00:02:32,560 when the crews go to the bathroom there 81 00:02:37,750 --> 00:02:35,760 is a toilet on board obviously 82 00:02:40,150 --> 00:02:37,760 but that that all goes inside the toilet 83 00:02:41,750 --> 00:02:40,160 at home it all goes into a main dump 84 00:02:42,949 --> 00:02:41,760 area that if you want to sample it 85 00:02:44,309 --> 00:02:42,959 you're out of luck 86 00:02:46,150 --> 00:02:44,319 so when we do experiments what we have 87 00:02:47,430 --> 00:02:46,160 to do is the crew uses 88 00:02:48,630 --> 00:02:47,440 these devices 89 00:02:51,110 --> 00:02:48,640 and this is what's called a urine 90 00:02:53,990 --> 00:02:51,120 collection device 91 00:02:55,430 --> 00:02:54,000 it's just a plastic type bag 92 00:02:56,470 --> 00:02:55,440 what happens is the crew will void into 93 00:03:00,550 --> 00:02:56,480 the bag 94 00:03:01,990 --> 00:03:00,560 lithium chloride which is just a 95 00:03:03,830 --> 00:03:02,000 chemical salt 96 00:03:06,710 --> 00:03:03,840 and we add that lithium chloride a small 97 00:03:08,630 --> 00:03:06,720 amount of it to the bag before it flies 98 00:03:09,990 --> 00:03:08,640 we do that in the lab two doors down 99 00:03:11,190 --> 00:03:10,000 well what happens is we can't bring this 100 00:03:13,589 --> 00:03:11,200 whole bag back 101 00:03:15,509 --> 00:03:13,599 so the crew will void into the bag 102 00:03:18,070 --> 00:03:15,519 they'll mix the urine by pressing on the 103 00:03:19,509 --> 00:03:18,080 bag so the lithium chloride gets mixed 104 00:03:20,710 --> 00:03:19,519 in with the urine 105 00:03:22,229 --> 00:03:20,720 and what happens is i'll take one of 106 00:03:23,589 --> 00:03:22,239 these syringes 107 00:03:26,550 --> 00:03:23,599 and then out of the other end of the bag 108 00:03:28,630 --> 00:03:26,560 they will take the lid off the syringe 109 00:03:29,509 --> 00:03:28,640 pop it in this little rubber opening 110 00:03:33,270 --> 00:03:29,519 here 111 00:03:36,149 --> 00:03:33,280 and we'll then withdraw a urine sample 112 00:03:38,390 --> 00:03:36,159 and easy as that easy as that and 113 00:03:39,990 --> 00:03:38,400 they'll put the cap back on here 114 00:03:42,390 --> 00:03:40,000 this gets pulled out to the end and then 115 00:03:44,470 --> 00:03:42,400 the white piece breaks off 116 00:03:45,670 --> 00:03:44,480 and this syringe part is what goes in 117 00:03:48,789 --> 00:03:45,680 the freezer 118 00:03:51,110 --> 00:03:48,799 space station until 119 00:03:53,190 --> 00:03:51,120 there's a spacex vehicle coming home 120 00:03:54,070 --> 00:03:53,200 realize that when they void into this 121 00:03:55,350 --> 00:03:54,080 bag 122 00:03:57,350 --> 00:03:55,360 typically they collect three of these 123 00:03:58,949 --> 00:03:57,360 syringes out of that bag 124 00:03:59,990 --> 00:03:58,959 because this supports not only our 125 00:04:01,350 --> 00:04:00,000 experiment but a number of other 126 00:04:03,030 --> 00:04:01,360 experiments so 127 00:04:05,750 --> 00:04:03,040 um we do take a little bit more out of 128 00:04:07,670 --> 00:04:05,760 each void okay so let's talk about your 129 00:04:09,910 --> 00:04:07,680 experiments you've finished a nutrition 130 00:04:12,070 --> 00:04:09,920 experiment you've finished a pro k 131 00:04:14,070 --> 00:04:12,080 experiment tell us about that and then 132 00:04:16,310 --> 00:04:14,080 the biochem that's the big one that's 133 00:04:19,189 --> 00:04:16,320 going on indeed um well the nutrition 134 00:04:21,270 --> 00:04:19,199 study that we finished was was literally 135 00:04:23,110 --> 00:04:21,280 uh simple let's collect blood and urine 136 00:04:24,469 --> 00:04:23,120 and see what happens during flight um 137 00:04:25,990 --> 00:04:24,479 that went very well and what happened 138 00:04:27,749 --> 00:04:26,000 when that one ended is there was a 139 00:04:28,469 --> 00:04:27,759 decision 140 00:04:32,390 --> 00:04:28,479 to 141 00:04:34,150 --> 00:04:32,400 and that's what the biochemical profile 142 00:04:36,469 --> 00:04:34,160 study is and we're looking 143 00:04:37,749 --> 00:04:36,479 for that to give us a broad 144 00:04:39,430 --> 00:04:37,759 broad look at 145 00:04:42,150 --> 00:04:39,440 crew biochemistry 146 00:04:44,150 --> 00:04:42,160 that we can then relate to changes in 147 00:04:45,990 --> 00:04:44,160 diet changes and exercise changes in 148 00:04:48,230 --> 00:04:46,000 other countermeasures that we're testing 149 00:04:50,550 --> 00:04:48,240 on space station so we provide 150 00:04:52,390 --> 00:04:50,560 information to the space station program 151 00:04:54,469 --> 00:04:52,400 and a lot of the other scientists that 152 00:04:55,909 --> 00:04:54,479 have studies going on on station so how 153 00:04:56,710 --> 00:04:55,919 does this all relate to us on earth 154 00:04:59,749 --> 00:04:56,720 though 155 00:05:01,749 --> 00:04:59,759 um well you know it it depends on on 156 00:05:03,110 --> 00:05:01,759 each facet but i would tell you that in 157 00:05:05,590 --> 00:05:03,120 my opinion 158 00:05:07,029 --> 00:05:05,600 everything we do in space relates in one 159 00:05:08,150 --> 00:05:07,039 way or the other to what's happening on 160 00:05:09,670 --> 00:05:08,160 earth 161 00:05:11,350 --> 00:05:09,680 you mentioned the pro case study which 162 00:05:15,350 --> 00:05:11,360 is a study we're looking at 163 00:05:17,189 --> 00:05:15,360 to modify the diet to help mitigate bone 164 00:05:18,070 --> 00:05:17,199 loss and what we're specifically trying 165 00:05:19,510 --> 00:05:18,080 to do 166 00:05:22,230 --> 00:05:19,520 is to decrease the amount of animal 167 00:05:23,909 --> 00:05:22,240 protein people consume and increase the 168 00:05:24,950 --> 00:05:23,919 amount of fruits and vegetables people 169 00:05:26,550 --> 00:05:24,960 consume 170 00:05:27,510 --> 00:05:26,560 and we think that by doing those two 171 00:05:29,029 --> 00:05:27,520 things 172 00:05:30,390 --> 00:05:29,039 and that is the ratio of those two 173 00:05:32,550 --> 00:05:30,400 things 174 00:05:34,870 --> 00:05:32,560 that you'll lose less bone 175 00:05:36,550 --> 00:05:34,880 so we we fed the crews different diets 176 00:05:38,950 --> 00:05:36,560 collected blood and urine and are now 177 00:05:40,950 --> 00:05:38,960 looking at how the diet affected that 178 00:05:42,950 --> 00:05:40,960 metabolism now 179 00:05:45,110 --> 00:05:42,960 that relates obviously 180 00:05:46,629 --> 00:05:45,120 to all of us here on earth 181 00:05:49,909 --> 00:05:46,639 and will help us better understand the 182 00:05:51,430 --> 00:05:49,919 relationship of diet with bone 183 00:05:53,590 --> 00:05:51,440 and you know the people that make the 184 00:05:55,990 --> 00:05:53,600 dietary recommendations for 185 00:05:57,749 --> 00:05:56,000 americans 186 00:05:59,749 --> 00:05:57,759 read our scientific papers as they do 187 00:06:01,670 --> 00:05:59,759 many other scientific papers and we 188 00:06:03,189 --> 00:06:01,680 contribute to that body of knowledge 189 00:06:04,150 --> 00:06:03,199 that helps them make decisions that 190 00:06:06,070 --> 00:06:04,160 affect 191 00:06:08,230 --> 00:06:06,080 everybody i know you have a lot of 192 00:06:10,150 --> 00:06:08,240 samples to get to so we're going to let